Together with Manali Ghosh, postdoctoral researcher at Purdue University, we are thinking about using electrowetting technology (EWOD) for cryo-electron microscopy (cryo-EM) sample preparation. Can the sample diffusion process be improved by continuously dispersing, moving and rotating a 1-3 uL sample on the Transmission Electron Microscopy (TEM) grid surface? The process of TEM grid sample preparation is very laborious at the current state and more like an art. Can other parts of the process be controlled and standardized using digital microfluidics?  First configurations of integration of the two technologies were sketched and discussed and first tests are promissing.